GEM + CBDCA regimen (n = 17) | PTX + CBDCA regemen (n = 15) | G 1/2 | |||||
n (% of patients) | n (% of patients) | ||||||
Toxicity | G 1/2 | G 3/4 | G 1/2 (%) | G 1/2 | G 3/4 | G 1/2 (%) | p value |
Nausea | 8 | 0 | 47.1 | 10 | 0 | 66.7 | 0.2645 |
Vomiting | 1 | 0 | 5.9 | 2 | 0 | 13.3 | 0.4705 |
Anorexia | 11 | 0 | 64.7 | 14 | 0 | 93.3 | 0.0506 |
Fatigue | 15 | 0 | 88.2 | 11 | 0 | 73.3 | 0.2811 |
Diarrhea | 0 | 0 | 0 | 0 | 0 | 0 | - |
Constipation | 8 | 0 | 47.1 | 5 | 0 | 33.3 | 0.4302 |
ALT/AST | 10 | 0 | 58.8 | 3 | 0 | 20 | 0.0256 |
Creatinine | 2 | 0 | 11.8 | 1 | 0 | 6.7 | 0.6215 |
Neurolopathy | 0 | 0 | 0 | 0 | 0 | 0 | - |
Pain, joint | 1 | 0 | 5.9 | 0 | 0 | 0 | 0.3399 |
Pain, muscle | 1 | 0 | 5.9 | 2 | 0 | 13.3 | 0.4705 |
Skin rash | 1 | 0 | 5.9 | 1 | 0 | 6.7 | 0.9271 |
Alopecia | 0 | 0 | 0 | 14 | 0 | 93.3 | <0.0001 |
Infection | 0 | 0 | 0 | 0 | 1* | 0 | - |
Fever | 1 | 0 | 5.9 | 2 | 0 | 13.3 | 0.4705 |
Others (Hearing) | 1 | 0 | 5.9 | 0 | 0 | 0 | 0.3399 |